Department of Experimental Clinical Oncology

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512..     Baumann, M., Bentzen, S.M. & Ang, K.K: Hyperfractionated radiotherapy in head and neck cancer: a second look at the clinical data (Invited editorial) Radiotherapy and Oncology 46: 127-130, 1998.

513.      Aboagye, E.O., Maxwell, R.J., Horsman, M.R., Lewis, A.D., Workman, P., Tracy, M. & Griffiths, J.R.: The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554. Br. J. Cancer 77: 65-70, 1998.

514.      Bentzen, S.M.: Towards evidence based radiation oncology: Improving the design, analysis, and reporting of clinical outcome studies in radiotherapy. Radiotherapy and Oncology 46: 5-18, 1998.

515.      Bentzen, S.M. & Tucker, S.L.: Individualization of radiotherapy dose prescription by means of in vitro radiosensitivity assay (Letter to the Editor). Radiotherapy and Oncology 46: 217-219, 1998.

516.      Borre, M.: A study of prostate cancer: Based on the natural history, therapeutic intervention and survival in citizens of Aarhus county diagnosed with prostate cancer in the five year period 01.01.1979-31.12.1983.  Ph.D. Thesis, Faculty of Health Sciences, University of Aarhus , 1998.

517.      Borre, M., Bentzen, S.M., Nerstrøm, B. & Overgaard, J.: Tumor cell proliferation and survival in patients with prostate cancer followed expectantly. J. Urology 159: 1609-1614, 1998.

518.      Borre, M., Høyer, M., Brandt Sørensen, F., Nerstrøm, B. & Overgaard, J.: Association between in vivo iododeoxyuridine labelling, MIB-1 expression, malignancy grade and clinical stage in human prostate cancer. APMIS 106: 389-395, 1998.

519.      Borre, M., Høyer, M., Nerstrøm, B. & Overgaard, J.: DNA ploidy and survival of patients with clinically localized prostate cancer  treated without intent to cure. The Prostate 36: 244-249, 1998. 

520.      Borre, M., Offersen, B.V., Nerstrøm, B. & Overgaard, J.: Microvessel density predicts survival in prostate cancer patients subjected to watchful waiting. Br. J. Cancer 78: 940-944, 1998.

521.      Borre, M., Stausbøl-Grøn, B.,  Nerstrøm, B. & Overgaard, J.: Immunohistochemical BCL-2 and Ki-67 expression predict survival in prostate cancer patients followed expectantly. Prostate Cancer and Prostatic Diseases 5: 268-275, 1998.

522.      Burnett, N.G., Johansen, J., Turesson, I., Nyman, J. & Peacock, J.H.: Describing patients' normal tissue reactions: concerning the possibility of individualising radiotherapy dose prescriptions based on potential predictive assays of normal tissue radiosensitivity. Int. J. Cancer 79: 606-613, 1998.

523.      Ejsing, O.: A study on radiation induced fibrosis added to the effect of tamoxifen, which may stimulate to fibrosis by elevating transforming growth factor beta. Diploma study (Master of Science), Faculty of Health Sciences, University of Aarhus, 1998.

524..     Godballe, C., Asschenfeldt, P., Jørgensen, K.E., Bastholt, L., Clausen, P.P., Hansen, T.P., Hansen, O. & Bentzen, S.M.: Prognostic factors in papillary and follicular thyroid carcinomas: p53 expression a significant indicator of prognosis.Laryngoscope 108: 243-249, 1998.

525.      Hansen, H.S., Overgaard, J. & Jørgensen, K.E.: DAHANCA - 20 års samarbejde. Ugeskr. Læg. 160: 821-826, 1998.

526.      Hansen, L.L., Andersen, J. Overgaard, J. & Kruse, T.A.: Molecular genetic analysis of easily accessible breast tumour DNA, purified from tissue left over from hormone receptor measurement.  APMIS 106: 371-377, 1998.

527.      Hansen, L.L., Yilmaz, M., Overgaard, J., Andersen, J. & Kruse, T.A.: Allelic loss of 16q23.2-24.2 is an independent marker of good prognosis in primary breast cancer. Cancer Res 58: 2166-2169, 1998.                    

528.      Herskind, C., Bentzen, S.M., Overgaard, J., Overgaard, M., Bamberg, M., Rodemann, H.P.: Differentiation state of skin fibroblast cultures versus risk of subcutaneous fibrosis after radiotherapy. Radiotherapy and Oncology 47: 263-269, 1998.

529.      Horsman, M.R.: Keynote address: measurement of tumour oxygenation.  Int. J. Radiat. Oncol. Biol. Phys. 42: 701-704, 1998.

530.      Horsman, M.R., Alsner, J. & Overgaard, J.: The effect  of shark cartilage extracts on the growth and metastatic spread of the SCCVII carcinoma. Acta Oncol. 37: 441-445, 1998.

531.      Horsman, M.R., Ehrnrooth, E., Ladekarl, M. & Overgaard, J.: The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors.  Int. J. Radiat. Oncol. Biol. Phys. 42: 895-898, 1998.

532.      Horsman, M.R., Nordsmark, M. & Overgaard, J.: Techniques to assess the oxygenation of human tumors. State of the art.Strahlentherap. Onkol. 174 (Suppl IV): 2-5, 1998.

533.      Høyer, M., Jørgensen, K., Bundgaard, T., Johansen, L.V., Bentzen, S.M., Overgaard, M., Hansen, O., Søgaard, H. & Overgaard, J.: Lack of predictive value of potential doubling time and iododeoxyuridine labelling index in radiotherapy of squamous cell carcinoma of the head and neck. Radiotherapy and Oncology 46: 147-155, 1998.

534.      Jensen, V., Sørensen, F.B., Bentzen, S.M.., Ladekarl, M., Nielsen, O.S., Keller, J. & Jensen, O.M.: Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas: a retrospective immunohistological study including 216 soft tissue sarcomas. Histopathology 32:: 536-546, 1998.

535.      Johansen, J., Streffer, C., Fuhrmann, C., Bentzen, S.M., Stausbøl-Grøn, B., Overgaard, M. & Overgaard, J.: Radiosensitivity of normal fibroblasts from  breast cancer patients assessed by the micronucleus and colony assays. Int. J. Radiat. Biol. 73: 671-678, 1998.

536.      Knoop, A.S., Andreasen, P.A., Andersen, J.A., Hansen, S., Lænkholm, A-V., Simonsen, ACW, Andersen, J. Overgaard, J. & Rose, C.: Prognostic significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in primary breast cancer. Br. J. Cancer 77: 932-940, 1998.

537.      Lundby, L.: Biomechanical and morphometric evaluation of late radiation-induced changes in the mouse rectum. Ph.D. Thesis, Faculty of Health Sciences, University of Aarhus, 1998.

538.      Maxwell, R.J. Nielsen, F.U., Breidahl, T., Stødkilde-Jørgensen, H. & Horsman, M.R. Effects of combretastatin on murine tumours monitored by 31P MRS, 1H MRS and 1H MRI. Int. J. Radiat. Oncol. Biol. Phys.42: 891-894, 1998.

539.      Nielsen, O.S., Bentzen, S.M., Sandberg, E., Gadeberg C.C. & Timothy, A.R.: Randomized trial of single dose versus fractionated palliative radiotherapy of bone metastases. Radiotherapy and Oncology 47: 233-240, 1998.

540.      Offersen, B., Borre, M. & Overgaard, J.: Immunohistochemical determination of tumour angiogenesis measured by the maximal microvessel density in human prostate cancer. APMIS 106: 463-469, 1998.

541.      Overgaard, J.: Nimorazole as hypoxic radiosensitizer in head and neck cancer (Letter to the Editor). Radiotherapy and Oncology 48: 345-346, 1998.

542.      Overgaard, J. & Bentzen, S.M..: Evidence based radiation oncology (editorial). : Radiotherapy and Oncology 46: 1-3, 1998.

543.      Overgaard, J., Hansen, H.S., Overgaard, M., Bastholt, L., Berthelsen, A., Specht, L., Lindeløv, B. & Jørgensen, K.: A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) protocol 5-85. Radiotherapy and Oncology 46: 135-146, 1998.

544.      Overgaard, J., Hansen, H.S., Overgaard, M., Grau, C., Bastholt, L., Jørgensen, K., Hansen, O., Specht, L., Pedersen , M. & Evensen, J.: Importance of overall treatment time for the outcome of radiotherapy in head and neck carcinoma. Experience from the Danish Head and Neck Cancer Study. In: Kogelnik. H.D. & Sedlmayer, F. (eds.): Progress in Radio-Oncology VI. Monduzzi Editore, Bologna, pp 743-752, 1998.

545..     Pfeiffer, P., Nexø, E., Bentzen, S.M., Clausen,  P.P.,  Andersen, K., Rose, C.: Enzyme-linked immunosorbent assay of epidermal growth factor receptor in lung cancer: comparisons with immunohistochemistry, clinicopathological features and prognosis. Br. J. Cancer 78: 96-99, 1998.

546.      Raleigh, J.A., Chou, S.-C., Tables, L., Suchindran, S., Varia, M.A. & Horsman, M.R. Relationship of hypoxia to metallothionein expression in murine tumors. Int. J. Radiat. Oncol. Biol. Phys. 42: 727-730, 1998.

547.      Rask, C.U., Albertioni, F., Bentzen, S.M., Schroeder, H. & Petterson, C.: Clinical and pharmacokinetic risk factors for high-dose methotrexate-induced toxicity in children with acute lymphoblastic leukemia - A logistic regression analysis. Acta Oncologica 37: 277-284, 1998.

548..     Siemann, D.W., Johansen, I.M. & Horsman, M.R.: Radiobiological hypoxia in the KHT sarcoma: predictions using the Eppendorf histograph. Int. J. Radiat. Oncol. Biol. Phys. 40: 1171-1176, 1998.

549..     Stausbøl-Grøn, B., Havsteen, H. & Overgaard, J.:Fibroblast growth in the soft agar clonogenic assay for cervix cancer radiosensitivity. Br. J. Cancer 78: 550-551, 1998.

550..     Stausbøl-Grøn, B., Bentzen, S.M. & Overgaard, J.: Characterization and radiosensitivity of fibroblasts derived from squamous cell carcinomas of  the head and neck, and the surrounding oral mucosa. Acta Oncol 37: 697-700, 1998.

551.      Stüben, G., Stuschke, M., Knühmann, K., Horsman, M.R. & Sack, H.: The effect of combined nicotinamide and carbogen treatments in human tumour xenografts: oxygenation and tumor control studies.  Radiotherapy and Oncology 48:143-148, 1998.

552.      Van der Zee, J., Gonzalez Gonzalez, D., Vernon, C.C., Overgaard, J., Valdagni, R., Sneed, P. & Dahl, O.: Therapeutic gain by hyperthermia added to radiotherapy. In: Kogelnik. H.D. & Sedlmayer, F. (eds.): Progress in Radio-Oncology VI.Monduzzi Editore, Bologna, pp 137-145, 1998.

553.      Work, E.: En undersøgelse af virkningen af strålebehandling ved småcellet anaplastisk lungecancer. Ph.D. Thesis, Faculty of Health Sciences, University of Aarhus, 1998.