Department of Experimental Clinical Oncology

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432.      Bartkova, J., Lukas, J., Guldberg, P., Alsner, J., Kirkin, A.F., Zeuthen, J. & Bartek, J.: The p16-cyclin D/Cdk4-pRb pathway a a functional unit frequently altered in melanoma pathogenesis. Cancer Res. 56: 5475-5483, 1996.

433.      Bastholt, L., Dalmark, M., Gjedde, S., Pfeiffer, P., Pedersen, D., Sandberg, E., Kjær, M., Mouridsen, H.T., Rose, C., Nielsen, O.S., Jakobsen P. & Bentzen, S.M.: Dose response relationship of Epirubicin in the treatment of postmenopausal patients with metastatic breast cancer. A randomized study of Epirubicin at four different dose levels performed by the Danish Breast Cancer Cooperative Group. J. Clin. Oncol. 14: 1146-1155, 1996.

434.      Bentzen, S.M.: Estimation of radiobiological parameters from clinical data. In: Hagen, U. et al. (eds): Radiation Research 1895-1995. Vol 2, 10th ICRR Society, Würzburg, pp. 833-838, 1996.

435.      Bentzen, S.M., Skoczylas, J.Z., Overgaard, M. & Overgaard, J.: Radiotherapy-related lung fibrosis enhanced by Tamoxifen. J. Natl. Cancer Inst. 88: 918-922, 1996.

436.      Bentzen, S.M., Skoczylas, J.Z., Overgaard, M., Overgaard, J.. Nielsen, O.G. & Hjøllund-Madsen, E.: Quantitative assessment of radiation-induced lung changes by computerized optical densitometry of routine chest x-rays. Int. J. Radiat. Oncol. Biol. Phys. 34: 421-427, 1996.

437.      Bentzen, S.M., Ruifrok, A.C.C. & Thames, H.D.: Repair capacity and kinetics for human mucosa and epithelial tumors in the head and neck: clinical data on the effect of changing the time-interval between multiple fractions per day in radio-therapy. Radiotherapy and Oncology 38: 89-101, 1996.

438.      Bentzen, S.M. & Thames, H.D.: Dose-response relationships for late radiation effects in the head and neck - Regarding the analysis of the RTOG 8313 trial, Fu et al. IJROBP 32: 577-588, 1995 (letter to the editor). Int. J. Radiation Oncol. Biol. Phys. 34: 523-524, 1996.

439.      Bentzen, S.M. & Thames, H.D.: Tumor volume and local control probability: clinical data and radiobiological interpretations. Int. J. Radiation Oncol. Biol. Phys. 36: 247-251, 1996.

440.      Bundgaard, T., Bentzen, S.M., Wildt, J., Sørensen, F.B., Søgaard, H. & Nielsen, J.E.: Histopathologic, stereologic, epidemiologic, and clinical parameters in the prognostic evaluation of squamous cell carcinoma of the oral cavity. Head and Neck 18: 142-152, 1996.

441.      Charabi, S., Engel, P. Charabi, B., Jakobsen, G.K., Overgaard, J., Thomsen, J. & Tos, M.: The cycling pool of cells in vestibular swannoma: in situ growth model employing the monoclonal antibody Ki-67 and DNA flowcytometry. Am. J. Otolaryngol. 17: 301-306, 1996.

442.      Grau, C. & Overgaard, J.: Posiirradiation sensorineural hearing loss: A common but ignored late radiation complication (editorial). Int. J. Radiation Oncology Biol. Phys. 36: 515-517, 1996.

443.      Gyldenhof, B., Horsman, M.R. & Overgaard, J. Hyperthermia-induced changes in the vascularity and histopathology of a murine tumour and its surrounding normal tissue. in: Franconi, C., Arcangeli, G. & Cavaliere, R. (eds). Hyperthermic Oncology 1996, Vol 2. Tor Vergata, Rome, pp. 780-782, 1996.

444.      Hansen, O., Grau, C., Bentzen, S.M. & Overgaard, J.: Repopulation in a SCCVII squamous cell carcinoma assessed by an in vivo - in vitro exicision assay. Radiotherapy and Oncology 39: 137-144, 1996.

445.      Hendry, J.H., Bentzen, S.M., Dale, R.G., Fowler, J.F., Wheldon, T.E., Jones, B., Mynro, A.J., Slevin, N.J. & Robertson, A.G.: A modelled comparison of the effects of using different ways to compensate for missed treatment days in radiotherapy. Clinical Oncology 8: 297-307, 1996.

446.      Horsman, M.R.: Nicotinamide and other benzamide analogs as agents for overcoming hypoxic cell radiation resistance in tumours. Dr. med. Thesis, Faculty of Health Science, University of Aarhus, 1996.

447.      Horsman, M.R., Chaplin, D.J., Hill, S.A.,  Arnold, S., Collingridge, D., Radacic, M., Wood, P.J. & Overgaard, J.: Effect of nitro-L-arginine on blood flow, oxygenation, and the activity of hypoxic cell cytotoxins in murine tumours. Br. J. Cancer 74 (Suppl. XXVII) S168-S171, 1996.

448.      Horsman, M.R. & Overgaard, J. Improved oxygenation in an experimental tumour by low thermal-dose hyperthermia. in: Franconi, C., Arcangeli, G. & Cavaliere, R. (eds). Hyperthermic Oncology 1996, Vol 2. Tor Vergata, Rome, pp. 777-779, 1996.

449.      Horsman, M.R., Sampson, L.E., Chaplin, D. & Overgaard, J.: The in vivo interaction between flavone acetic acid and hyperthermia. Int. J. Hyperthermia 12: 779-789, 1996.

450.      Jensen, V. Høyer, M., Sørensen, F.B., Keller, J. & Myhre Jensen, O.: MIB-1 expression and iododeoxyuridine labelling in soft tissue sarcomas. An immunohistochemical study including correlations with p53, bcl-2 expression and histological characteristics. Histopathology, 28: 1-13, 1996.

451.      Johansen, J., Bentzen, S.M., Overgaard, J. & Overgaard, M.: Relationship between the in vitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia and skin erythema after radiotherapy. Radiotherapy and Oncology 40: 101-109, 1996.

452.      Judas, L., Bentzen, S.M., Hansen. P.V. & Overgaard, J.: Proliferative response of mouse spermatogonial stem cells after irradiation: a quantitative model analysis of experimental data. Cell Proliferation 29: 73-87, 1996.

453.      Keldsen, N., Michalski, W., Bentzen, S.M. & Thorling, K.: Risk factors for central nervous system involmement in non-Hodgkins lymphoma - A multivariate analysis. Acta Oncologica 35: 703-708, 1996.

454.      Khalil, A.A.: Experimental studies on the relationship between tomour growth and different cellular and tissue environmental parameters of a malignant solid tumour. Ph.D. Thesis, Faculty of Health Science, University of Aarhus, 1996.

455.      Lindegaard, J.C., Overgaard, J., Bentzen, S.M. & Pedersen, D. Is there a radiobiological basis for improving the treatment of advanced stage cervical cancer. Mogr. Natl. Cancer Inst. 21: 105-112, 1996.

456.      Nordsmark, M: Direct measurements of tumor-tissue pO2. A way of selecting patients for hyperoxic treatment. Strahlen-ther. Onkol. 172 (Suppl.II): 8-9,1996.

457.      Nordsmark, M., Høyer, M., Keller, J., Nielsen, O.S., Myhre Jensen, O. & Overgaard, J.: The relationship between tumor oxygenation and cell proliferation in human soft tissue sarcomas. Int. J. Radiation Oncol. Biol. Phys. 35: 701-708, 1996.

458.      Nordsmark, M., Maxwell, R.J., P.J. Wood, P.J., Stratford, I.J., Adams, G.E., Overgaard, J. & Horsman, M.R.: Effect of hydralazine in spontaneous tumours assessed with oxygen electrodes and 31P-magnetic resonance spectroscopy. Br. J. Cancer 74 (Suppl. XXVII): S232-S235, 1996.

459.      Nordsmark, M., Overgaard, M.  Overgaard, J.: Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiotherapy and Oncology 41: 31-40, 1996.

460.      Olsson, A.R., Sheng, Y., Pero, R.W., Chaplin, D.J. & Horsman, M.R.: DNA damage and repair in tumour and non-tumour tissues of mice induced by nicotinamide. Br. J. Cancer 74: 368-373, 1996.

461.      Overgaard, J: Thermoradiotherapy of malignant melanoma. In: Seegenschmiedt. M.H., Fessenden. P. & Vernon, C. (eds.) Thermoradiotherapy and Thermochemotherapy vol. 2. Medical Radiology, Springer-Verlag, Berlin, pp. 69-83, 1996.

462.      Overgaard, J.: Uveal malignant melanoma. An ophtalmological or oncological disease?. (invited editorial). Acta Ophtalmol. Scand. 74: 133, 1996.

463.      Overgaard, J., Gonzalez Gonzalez, D., Hulshof, M.C.C.M., Arcangeli, G., Dahl, O., Mella, O. & Bentzen, S.M.: Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma (ESHO 3-85). A multicenter randomized trial by the European Society for Hyperthermic Oncology. Int. J. Hyperthermia 12: 3-20, 1996.

464.      Overgaard, J. & Horsman, M.R.: Modification of hypoxia induced radioresistance in tumours by the use of oxygen and sensitizers. Sem. Rad. Oncol. 6: 10-21, 1996.

465.      Overgaard, J. & Horsman, M.R.: Hyperthermic radiosensitization in the treatment of solid tumors - experience from mice and men. In: Hagen, U. et al. (eds): Radiation Research 1895-1995. Vol 2, 10th ICRR Society, Würzburg, pp. 997-1000, 1996.

466.      Radacic, M., Horsman, M.R., Eljuga, G., Jercic, J. & Overgaard, J. The antitumour effect of etoposide is potentiated by heat. in: Osmark, M. & Skrk, J. (eds). Molecular Oncology Today, Croatian Ligue against Cancer, Zagreb, pp. 191-195, 1996.

467.      Radacic, M., Horsman, M.R., Eljuga, G. & Overgaard, J. The in vivo interaction between etoposide, ifosphamide and hyperthermia in a C3H mouse mammary carcinoma. in: Franconi, C., Arcangeli, G. & Cavaliere, R. (eds). Hyperthermic Oncology 1996, Vol 2. Tor Vergata, Rome, pp. 630-632, 1996.

468.      Safwat, A., Bentzen, S.M., Nielsen, O.S., Mahmoud, H.K. & Overgaard, J.: Repair capacity of mouse lung after total body irradiation alone or combined with cyclophosphamide. Radiotherapy and Oncology 40: 249-257.

469.      Safwat, A., Nielsen, O.S., El-Badawy, S. & Overgaard, J.: Effect of radiation dose rate and cyclophosphamide on pulmonary toxicity after total body irradiation in a mouse model. Int. J. Radiat. Oncol. Biol. Phys. 34: 85-91, 1996.

470.      Storm, H.H. & Overgaard, J.: Cancer registretion in the Arctic - a useful research tool (editorial). Acta Oncologica 35: 521-522, 1996.

471.      Vernon, C.C., van der Zee, J., Overgaard, J. & Gonzalez Gonzalez, D.: Superficial hyperthermia. In: Hagen, U. et al. (eds): Radiation Research 1895-1995. Vol 2, 10th ICRR Society, Würzburg, pp. 1005-1008, 1996.

472.      Wood, P.J., Horsman, M.R., Khalil, A.A., Steinberg, F., Streffer, C., Overgaard, J., Stratford, I.J. & Adams, G.E.: A Comparison of the physiological effects of RSU 1069 and RB 6145 in the SCCVII murine tumour. Acta Oncologica 35: 989-994, 1996.

473.      Work, E., Bentzen, S.M., Nielsen, O.S., Fode, K., Michalski, W., Palshof, T. & The Aarhus Lung Cancer Group: Prophylactic cranial irradiation in limited stage small-cell lung cancer. survival benefits in patients with favourable characteristics. Eur. J. Cancer 32A: 772-778, 1996.